Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes
Research Article – European Journal of Medicinal Chemistry Reports (2024); DOI: 10.1016/j.ejmcr.2024.100145
MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality
Research Article – bioRxiv 2023.11.07.565938; DOI: 10.1101/2023.11.07.565938
Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound
Research Article – Journal of Pharmacy and Pharmacology Research 7 (2023): 177-191
The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells
Research Article – PLOS ONE (2023)
Orally bioavailable 4-phenoxy-quinoline compound as a potent Aurora Kinase B relocation blocker for cancer treatment
Research Article – ACS Pharmacology & Translational Science (2023)
In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis
Research Article – Journal of Pharmaceutical and Biomedical Analysis (2023), 115415
An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment
Research Article – BioRxiv (2023)
Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B
Research Article – Bioorganic & Medicinal Chemistry (2023), 117173
2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization
Research Article – European Journal of Medicinal Chemistry (2022), 114904
The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells
Research Article – International Journal of Molecular Sciences (2022), 23 (20), 12104
Powerful Molecule Generation with Simple ConvNet
Research Article – Bioinformatics (2022), DOI: 10.1093/bioinformatics/btac332
The Phytochemical, Corynoline, Diminishes Aurora Kinase B Activity to Induce Mitotic Defect and Polyploidy
Research Article – Biomedicine & Pharmacotherapy (2022), DOI: 10.1016/j.biopha.2022.112645
The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects
Research Article – Journal of Natural Products (2021), DOI: 10.1021/acs.jnatprod.1c00429
Mini-library approach delivers an arsenal in drug development pipeline
Article – Drug Discovery World (2021), 22 (3): 64-67
A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil
Research Article – PLOS One (2021), 16(3): e0248355
A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata
Research Article – Phytochemistry Letters (2021), 41: 180-185
Emerging Strategies to Attack Polyploid Cancer Cells
Review Article – Journal of Cellular Immunology (2020), 2 (4):199-206
Pro-survival Bcl-2 proteins are modifiers of MYC-VX-680 synthetic lethality
Commentary – Journal of Cellular Immunology (2020), 2 (5):227-232
The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells
Research Article – Experimental Cell Research (2020), 394 (1):112112