Architectural executability cannot be inferred from static measurements or endpoint effects; it must be evaluated under conditions that challenge the architecture’s capacity to continue executing.

SYMPLEX defines a stress-test regime in which malignant architectures under oncogenic load are subjected to controlled perturbations, and feasibility is assessed at the level of architecture-wide execution, not isolated molecular readouts.
Claims of architectural dependency are admitted only when perturbation induces collapse that cannot be locally contained or compensated.