Architectural Oncology is explicitly falsifiable. The framework would be invalidated if any of the following were consistently observed:
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No collapse boundary: Under high-demand conditions, proposed architectural dependencies can be perturbed (with confirmed perturbation) without producing architectural collapse (loss of executability) where the framework predicts a boundary should be crossed.
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Local sufficiency: Malignant persistence can be consistently maintained through local compensation alone, such that architecture-level constraints are not needed to account for continued execution.
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No collapse signature: Perturbations of a critical structural function remain domain-confined and do not produce the coordinated, cross-domain disruption pattern expected when collapse is architectural rather than local.