Resistance is commonly described as an adaptive response that emerges following therapeutic intervention. Architectural Oncology adopts a different interpretation.

In many malignant states, persistence reflects the continued feasibility of the underlying cellular architecture. As long as the structural coordination required for growth, division, and survival remains intact, execution can proceed despite effective disruption of local molecular functions.

From this perspective, what appears as resistance is often not newly acquired but an expression of continued architectural feasibility.